Mayo Clinic Ventures is continually seeking partners and strategic collaborators to help bring innovative technologies to market. We have hundreds of new disclosures each year from every facet of Mayo Clinic’s practice and are looking to license out these novel new technologies.
Our technology licensing experts function as the front door for active technology collaboration between industry and commercial groups with the end goal of producing meaningful and effective changes to improve patient health and medical care.
Mayo Clinic Ventures largely commercializes novel technologies in the following categories:
Technology types: biologics, small molecules, gene and cell therapies, vaccines
MSC-CAR
About: The Mesenchymal Stem Cell (MSC) therapy platform uses Chimeric Antigen Receptors (CAR) to treat autoimmune and degenerative diseases.
Application: Engineered mesenchymal stromal cells (MSCs) express Chimeric Antigen Receptors CARs (MSC-CAR) with optimized structure and signaling as a platform to enhance immunosuppression and trafficking to inflammatory sites.
Benefits: Potential for increased treatment effectiveness and efficiency, plus decreased cost.
Seeking: Licensing
BMP5 for Tendon Repair and Regeneration
About: The technology is a novel therapeutic approach using bone morphogenic protein 5 (BMP5) to repair and regenerate damaged rotator cuff tendons in the shoulder.
Application: It works by introducing BMP5 growth factor to the damaged rotator cuff tendon. BMP5 promotes enhanced extracellular matrix production, increased tendon strength, improved tendon gliding surface, and activates cell division and vascularization pathways to facilitate the healing of the rotator cuff.
Benefits: This technology aims to provide a new solution for patients suffering from rotator cuff tears, tendonitis, and preventive measures against future tears, with improved healing outcomes compared to current treatments.
Seeking: Development collaboration, Licensing
Technology types: devices, algorithms
Intraventricular Myocardial Recovery Device
About: An intraventricular implantable device for treating heart failure that offers the ability to augment cardiac function and allow potential myocardial recovery.
Application: The device is designed to operate in the absence of power, with the structure allowing for minimally invasive transplantation rather than open heart surgery and heart-lung machine support. Implanted within the left ventricle, the device will deploy in a closed form and subsequently expand to rest within the left ventricular cavity.
Benefits: This device would offer a minimally invasive treatment option for patients with advanced heart failure who may not be a candidate for the current treatment offerings.
Seeking: Development collaboration/Commercial collaboration /Licensing
Technology types: implantable/wearables, capital medical equipment, medical instruments
SUI Device
About: A urethral delivery device that allows for minimally invasive therapeutic treatments for stress urinary incontinence (SUI) in women.
Application: This device creates microinjuries along the length of the urethra allowing for more efficient uptake of regenerative therapies to improve sphincter function in females.
Benefits: Potential to improved SUI treatment outcomes and a better quality of life for female patients suffering from this condition.
Seeking: Licensing
Technology types: biomarkers, clinical lab tests
Biomarkers for CRPC
About: Researchers at Mayo have identified six polypeptides that can be used to identify castration resistant prostate cancer (CRPC).
Application: CRPC patients treated with enzalutamide typically show significant improvement in survival, but there is a subset of patients that develop resistance to this drug. Analysis using these biomarkers allows medical teams to see CRPC patients would better respond to other treatment options without time lost to trial and error.
Benefits: These findings can help identify patients with CRPC who will better respond to alternative forms of therapy, filling an unmet need in the management of CRPC.
Seeking: Development collaboration
Technology types: virtual reality, workflows, patient engagement tools, EHR, clinical decision support, population health, telemedicine, CRM/scheduling/access, supply chain/inventory management, security, analytics and business intelligence, revenue cycle management
American Society of Anesthesiologists (ASA) Scoring Tool
About: A software tool that uses natural language processing (NLP) algorithms and ICD-10 codes to identify relevant conditions in an effective and efficient way.
Application: Using NLP algorithms and ICD-10 codes, the tool reviews the patient’s electronic health record (EHR) and identifies relevant comorbid conditions to provide a recommended ASA score easily accessible within the EHR.
Benefits: Surgery teams can use this tool to inform safer and more effective delivery of anesthesia during procedures.
Seeking: Licensing
Technology types: joint replacements
Vertebral Tether
About: A system and surgical tool for treating scoliosis through anterior vertebral body tethering, which uses a tether to apply tension to correct spinal curvature.
Application: The surgeon attaches vertebral screws to the spine and then uses the surgical tool to connect the tether to these screws. By manually actuating the tool, tension is applied to the tether, gradually correcting the curvature of the spine.
Benefits: Offers a minimally invasive treatment option for scoliosis, particularly for patients with severe spinal curvature. Compared to traditional spinal fusion surgery, this technology can potentially reduce recovery times, patient discomfort, and treatment costs while maintaining a higher degree of patient mobility. It also allows for precise and controlled tether tension, which can lead to improved patient outcomes.
Seeking: Licensing
Technology types: 3D printing, imaging, magnetic resonance (MR), molecular breast imaging (MBI), positron emission tomography (PET), computerized tomography (CT), nuclear therapy, radiation therapy, proton therapy, single photon emission computed tomography (SPECT), ultrasound, x-ray, augmented human intelligence
qHDMI
About: Ultrasound technology to detect and diagnose malignancy without using imaging contrast.
Application: Collect ultrasound images along with Mayo’s proprietary software to detect, diagnose, and predict cancer within the patient.
Benefits: Other methods to detect and diagnose cancer are invasive and costly compared to using ultrasound – for example having to take biopsies or use a more advanced scanner like an MRI. Also, this does not require contrast agent to enhance the image thus saving time and costs to the patient as well.
Seeking: Licensing
Breast Cancer Imaging and Navigation
About: A technology package using high fidelity imaging and historical analytical data to inform treatment plans for breast cancer patients.
Application: This system takes data gathered during screening and treatment and compares it to Mayo Clinic’s ever-improving database to provide better understanding of relative patient disposition and comparative analysis of treatment options.
Benefits: Provides the radiologist with up-to-date insights & statistics, improving decision-making. Real-time analysis helps create an optimal care plan.
Seeking: Licensing
Technology types: questionnaires, mouse lines, cell lines and antibodies
UC Score
About: This questionnaire has been labeled the gold standard by FDA for evaluating ulcerative colitis patients and is used to assess disease severity.
Application: Individuals answer the questionnaire to give providers or researchers a consistent method to track the severity of the condition, whether it is improving, declining, or consistent, through the course of treatment.
Benefits: The questionnaire is often used in research studies where pharmaceutical companies are developing treatments for UC but can be used for everyday tracking of a patient’s symptoms as they undergo treatment.
Seeking: Licensing
MPN-SAF
About: A questionnaire to help track symptoms for individuals with Myeloproliferative Neoplasms (MPNs).
Application: Individuals answer the questionnaire, whether for clinical trial or clinical use, several times throughout the course of study or treatment to provide consistent information on if their symptoms improve or worsen.
Benefits: Easy format
Let’s start the conversation
Mayo Clinic’s technology portfolio is too large and everchanging to maintain a static list for distribution.
To learn what is available for licensing, please fill out the form below. By sharing your specific area(s) of interest, our staff can suggest technologies that best align.
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